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An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein.

Abstract:

A series of seven monoclonal antibodies was produced against the T-lineage-specific 50 kd T11 sheep erythrocyte rosette (SRBC) receptor protein in order to define the function of the molecule. Three distinct epitopes were detected: T11(1), the SRBC binding site expressed on all T lymphocytes and thymocytes; T11(2), an epitope unrelated to the SRBC binding site but with a similar distribution; and T11(3), a neo-epitope expressed only upon T-cell activation. Simultaneous triggering of T11(2) an...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Cell
Volume:
36
Issue:
4
Pages:
897-906
Publication date:
1984-04-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:397a142d-7ed3-4375-b734-04128fad632a
Source identifiers:
19893
Local pid:
pubs:19893

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