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Journal article

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.

Abstract:

We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity. In the present report, we aimed to examine the effect of increasing IGF-1R on endothelial cell function and repair. To examine the effect of increasing IGF-1R in the endothelium, we generated mice overexpressing human IGF-1R in the endothelium (human IGF-1R endothelium-overexpressing mice [hIGFREO]) under direction of th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.2337/db11-1494

Authors


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British Heart Foundation More from this funder
Medical Research Council More from this funder
Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
61
Issue:
9
Pages:
2359-2368
Publication date:
2012-06-25
Acceptance date:
2012-04-18
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
341122
Language:
English
Keywords:
UUID:
uuid:396eae77-dd2b-4b0a-b59d-95d6b2095146
Local pid:
pubs:341122
Deposit date:
2013-11-16

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