Journal article
StopCOVID cohort: an observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection
- Abstract:
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Background
The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking.Methods
We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020.Results
Of the 4261 patients hospitalized for suspected COVID-19, outcomes were available for 3480 patients (median age, 56 years; interquartile range, 45–66). The most common comorbidities were hypertension, obesity, chronic cardiovascular disease, and diabetes. Half of the patients (n = 1728) had a positive reverse transcriptase–polymerase chain reaction (RT-PCR), while 1748 had a negative RT-PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID-19. No significant differences in frequency of symptoms, laboratory test results, and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR. In a multivariable logistic regression model the following were associated with in-hospital mortality: older age (per 1-year increase; odds ratio, 1.05; 95% confidence interval, 1.03–1.06), male sex (1.71; 1.24–2.37), chronic kidney disease (2.99; 1.89–4.64), diabetes (2.1; 1.46–2.99), chronic cardiovascular disease (1.78; 1.24–2.57), and dementia (2.73; 1.34–5.47).Conclusions
Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features was sufficient to diagnose COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.
- Publication status:
- In press
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1093/cid/ciaa1535
Authors
- Publisher:
- Oxford University Press
- Journal:
- Clinical Infectious Diseases More from this journal
- Volume:
- 73
- Issue:
- 1
- Pages:
- 1–11
- Publication date:
- 2020-10-09
- Acceptance date:
- 2020-10-02
- DOI:
- EISSN:
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1537-6591
- ISSN:
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1058-4838
- Pmid:
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33035307
- Language:
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English
- Keywords:
- Pubs id:
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1137901
- Local pid:
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pubs:1137901
- Deposit date:
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2020-12-16
Terms of use
- Copyright holder:
- Munblit et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Oxford University Press at: https://doi.org/10.1093/cid/ciaa1535
- Licence:
- Other
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