A resource for improved predictions of Trypanosoma and Leishmania protein three-dimensional structure

Journal article

Leishmaniasis is a neglected tropical disease, which inflicts a variety of gruesome pathologies on humans. The number of individuals afflicted with leishmaniasis is thought to vary between 0.7 and 1.2 million annually, of whom it is estimated that 20 to 40 thousand die. This problem is exemplary of inequality in healthcare – current leishmaniasis treatments are inadequate due to toxicity, cost, and ineffectiveness, so there is an urgent need for improved chemotherapies. Ubiquitination is a...

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Authors: Wheeler, RJ

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Public Library of Science
• Journal: PLoS ONE
• Volume: 16
• Issue: 11
• Pages: e0259871-e0259871
• Publication date: 2021-11-11
• DOI: 10.1371/journal.pone.0259871
• EISSN: 1932-6203
• ISSN: 1932-6203
• Language: English
• Keywords: Protein structure; Trypanosoma brucei; Biochemistry; Protein structure prediction; Bioinformatics; Parasite hosting; Trypanosoma cruzi; Leishmania; Genetics; Protein sequencing; Leishmaniasis; Computational biology; Leishmania infantum; Visceral leishmaniasis; Computer science; Sequence alignment; Sequence (biology); Peptide sequence; Biology