IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis.

Journal article

Only around 80% of patients with generalized myasthenia gravis (MG) have serum antibodies to acetylcholine receptor [AChR; acetylcholine receptor antibody positive myasthenia gravis (AChR-MG)] by the radioimmunoprecipitation assay used worldwide. Antibodies to muscle specific kinase [MuSK; MuSK antibody positive myasthenia gravis (MuSK-MG)] make up a variable proportion of the remaining 20%. The patients with neither AChR nor MuSK antibodies are often called seronegative (seronegative MG, SNM...

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Authors: Leite, M; Jacob, S; Viegas, S; Cossins, J; Clover, L

• Publication status: Published
• Journal: Brain : a journal of neurology
• Volume: 131
• Issue: Pt 7
• Pages: 1940-1952
• Publication date: 2008-07-01
• DOI: 10.1093/brain/awn092
• EISSN: 1460-2156
• ISSN: 0006-8950
• Language: English
• Keywords: Humans; Receptors, Cholinergic; Fetus; Myasthenia Gravis; Adult; Cell Line; Binding Sites, Antibody; Autoantibodies; Antigen-Antibody Reactions; Immunoglobulin G; False Negative Reactions; Complement Activation; Immunoglobulin M; Receptor Protein-Tyrosine Kinases; Microscopy, Fluorescence; Thymus Gland