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A hierarchical atlas of the human cerebellum for functional precision mapping

Abstract:
The human cerebellum is activated by a wide variety of cognitive and motor tasks. Previous functional atlases have relied on single task-based or resting-state fMRI datasets. Here, we present a functional atlas that integrates information from seven large-scale datasets, outperforming existing group atlases. The atlas has three further advantages. First, the atlas allows for precision mapping in individuals: the integration of the probabilistic group atlas with an individual localizer scan results in a marked improvement in prediction of individual boundaries. Second, we provide both asymmetric and symmetric versions of the atlas. The symmetric version, which is obtained by constraining the boundaries to be the same across hemispheres, is especially useful in studying functional lateralization. Finally, the regions are hierarchically organized across three levels, allowing analyses at the appropriate level of granularity. Overall, the present atlas is an important resource for the study of the interdigitated functional organization of the human cerebellum in health and disease.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-024-52371-w

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0001-5427-2907


Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
15
Issue:
1
Article number:
8376
Place of publication:
England
Publication date:
2024-09-27
Acceptance date:
2024-08-30
DOI:
EISSN:
2041-1723
Pmid:
39333089


Language:
English
Pubs id:
2046734
Local pid:
pubs:2046734
Deposit date:
2025-09-03

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