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Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction.

Abstract:

BACKGROUND: Iron-related genes and iron status may independently contribute to variable HIV outcomes. The nature of the biologically plausible gene-nutrient interaction remains unknown. OBJECTIVES: The objectives were to investigate whether iron-related genotypes and clinically abnormal iron status independently predict mortality in HIV and whether a gene-nutrient interaction exists. DESIGN: Baseline plasma, DNA, and clinical data were obtained from 1362 HIV-seropositive Gambian adults follow...

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Publication status:
Published

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Publisher copy:
10.3945/ajcn.2009.27709

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Journal:
The American journal of clinical nutrition
Volume:
90
Issue:
1
Pages:
225-233
Publication date:
2009-07-05
DOI:
EISSN:
1938-3207
ISSN:
0002-9165
URN:
uuid:38c1ef08-618e-4870-9947-26edcc3ab77d
Source identifiers:
41234
Local pid:
pubs:41234

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