BACKGROUND: Iron-related genes and iron status may independently contribute to variable HIV outcomes. The nature of the biologically plausible gene-nutrient interaction remains unknown. OBJECTIVES: The objectives were to investigate whether iron-related genotypes and clinically abnormal iron status independently predict mortality in HIV and whether a gene-nutrient interaction exists. DESIGN: Baseline plasma, DNA, and clinical data were obtained from 1362 HIV-seropositive Gambian adults follow...Expand abstract
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Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction.
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