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DNA charge neutralization by linear polymers: irreversible binding.

Abstract:

We develop a deterministic mathematical model to describe the way in which polymers bind to DNA by considering the dynamics of the gap distribution that forms when polymers bind to a DNA plasmid. In so doing, we generalize existing theory to account for overlaps and binding cooperativity whereby the polymer binding rate depends on the size of the overlap. The proposed mean-field models are then solved using a combination of numerical and asymptotic methods. We find that overlaps lead to highe...

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Publication status:
Published

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Publisher copy:
10.1103/physreve.74.011904

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Journal:
Physical review. E, Statistical, nonlinear, and soft matter physics
Volume:
74
Issue:
1 Pt 1
Pages:
011904
Publication date:
2006-07-01
DOI:
EISSN:
1550-2376
ISSN:
1539-3755
Source identifiers:
319101
Language:
English
Keywords:
Pubs id:
pubs:319101
UUID:
uuid:38acb995-8a2c-418c-9207-ce71de581d37
Local pid:
pubs:319101
Deposit date:
2012-12-19

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