Journal article
Regulatory T cells for tolerance
- Abstract:
- Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, ppt, 790.0KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 528.9KB, Terms of use)
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(Preview, Accepted manuscript, pdf, 139.2KB, Terms of use)
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- Publisher copy:
- 10.1016/j.humimm.2017.12.013
Authors
- Publisher:
- Elsevier
- Journal:
- Human Immunology More from this journal
- Volume:
- 79
- Issue:
- 5
- Pages:
- 294-303
- Publication date:
- 2017-12-27
- Acceptance date:
- 2017-12-26
- DOI:
- EISSN:
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1879-1166
- ISSN:
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0198-8859
- Pmid:
-
29288698
- Language:
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English
- Keywords:
- Pubs id:
-
pubs:817654
- UUID:
-
uuid:3892a760-fc2b-49cf-82a4-2c1b3e2b865d
- Local pid:
-
pubs:817654
- Source identifiers:
-
817654
- Deposit date:
-
2018-11-21
Terms of use
- Copyright holder:
- American Society for Histocompatibility and Immunogenetics
- Copyright date:
- 2017
- Notes:
- Copyright © 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.humimm.2017.12.013
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