Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism

Journal article

Introduction: Ghrelin is a potent orexigenic brain-gut peptide with lipogenic and diabetogenic effects, possibly mediated by growth hormone secretagogue receptor (GHS-R1a). Cannabinoids also have orexigenic and lipogenic effects. AMPK is a regulator of energy homeostasis and we have previously shown that ghrelin and cannabinoids stimulate hypothalamic AMPK activity while inhibiting it in the liver and adipose tissue, suggesting that AMPK mediates both the central appetite-inducing and periphe...

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Authors: Lim, C; Kola, B; Feltrin, D; Perez-Tilve, D; Tschöp, M

• Journal: Molecular and Cellular Endocrinology
• Volume: 365
• Issue: 2
• Pages: 303-308
• Publication date: 2013-01-03
• DOI: 10.1016/j.mce.2012.11.007
• EISSN: 1872-8057
• ISSN: 0303-7207
• Language: English
• Keywords: Cannabinoid receptor type 1; Cannabinoids; Growth hormone secretagogue receptor knockout; Ghrelin; Ghrelin receptor; AMPK