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Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues

Abstract:
Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid using a bicyclic lactam as a synthetic template; diastereocontrolled modification of the pyrrolidine ring using a sequential conjugate addition-substitution strategy permits access to several kainoid analogues in a versatile strategy. The pyrrolidinone ring conformation appears to be controllable by the nature of remote substituents on the heterocyclic ring. © The Royal Society of Chemistry 2000.
Publication status:
Published

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Publisher copy:
10.1039/b002001j

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 More from this journal
Issue:
16
Pages:
2793-2804
Publication date:
2000-01-01
DOI:
EISSN:
1364-5463
ISSN:
1470-4358


Language:
English
Pubs id:
pubs:37529
UUID:
uuid:38831d00-bc92-4a4c-81fa-c2040fa5dee5
Local pid:
pubs:37529
Source identifiers:
37529
Deposit date:
2012-12-19

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