Journal article
Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues
- Abstract:
- Novel conformationally constrained glutamate analogues are readily available from (S)-pyroglutamic acid using a bicyclic lactam as a synthetic template; diastereocontrolled modification of the pyrrolidine ring using a sequential conjugate addition-substitution strategy permits access to several kainoid analogues in a versatile strategy. The pyrrolidinone ring conformation appears to be controllable by the nature of remote substituents on the heterocyclic ring. © The Royal Society of Chemistry 2000.
- Publication status:
- Published
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Authors
- Journal:
- JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 More from this journal
- Issue:
- 16
- Pages:
- 2793-2804
- Publication date:
- 2000-01-01
- DOI:
- EISSN:
-
1364-5463
- ISSN:
-
1470-4358
- Language:
-
English
- Pubs id:
-
pubs:37529
- UUID:
-
uuid:38831d00-bc92-4a4c-81fa-c2040fa5dee5
- Local pid:
-
pubs:37529
- Source identifiers:
-
37529
- Deposit date:
-
2012-12-19
Terms of use
- Copyright date:
- 2000
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