Malignant melanoma and bone resorption.

Journal article

The cellular and humoral mechanisms accounting for osteolysis in skeletal metastases of malignant melanoma are uncertain. Osteoclasts, the specialised multinucleated cells that carry out bone resorption, are derived from monocyte/macrophage precursors. We isolated tumour-associated macrophages (TAMs) from metastatic (lymph node/skin) melanomas and cultured them in the presence and absence of osteoclastogenic cytokines and growth factors. The effect of tumour-derived fibroblasts and melanoma c...

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Authors: Lau, Y; Sabokbar, A; Giele, H; Cerundolo, V; Hofstetter, W

• Publication status: Published
• Journal: British journal of cancer
• Volume: 94
• Issue: 10
• Pages: 1496-1503
• Publication date: 2006-05-01
• DOI: 10.1038/sj.bjc.6603103
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Membrane Glycoproteins; Female; Glycoproteins; Culture Media, Conditioned; Antineoplastic Agents; Macrophages; Fibroblasts; Tumor Necrosis Factor-alpha; Interleukin-1; Osteoprotegerin; Skin Neoplasms; Cells, Cultured; Receptor Activator of Nuclear Factor-kappa B; Middle Aged; Aged, 80 and over; Male; Receptors, Tumor Necrosis Factor; Cell Differentiation; Aged; Osteoclasts; Humans; Receptors, Cytoplasmic and Nuclear; Bone Resorption; Lymphatic Metastasis; Reverse Transcriptase Polymerase Chain Reaction; Carrier Proteins; Osteolysis; Melanoma; RANK Ligand