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Exploitation of acoustic cavitation-induced microstreaming to enhance molecular transport

Abstract:

Ultrasound (US) exposure of soft tissues, such as the skin, has been shown to increase permeability, enhancing the passage of drug molecules via passive processes such as diffusion. However, US regimes have not been exploited to enhance active convective transport of drug molecules from a donor layer, such as a gel, into another medium. A layered tissue-mimicking material (TMM) was used as a model for a drug donor layer and underlying soft tissue to test penetration of agents in response to a...

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Publisher copy:
10.1002/jps.23971

Authors


Publisher:
John Wiley and Sons Inc.
Journal:
Journal of Pharmaceutical Sciences
Volume:
103
Issue:
6
Pages:
1903-1912
Publication date:
2014-01-01
DOI:
EISSN:
1520-6017
ISSN:
0022-3549
URN:
uuid:3859fbfc-46a8-42a0-be83-66099ea9ada0
Source identifiers:
470250
Local pid:
pubs:470250

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