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Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle.

Abstract:

During blood infection, malarial parasites use D-glucose as their main energy source. The Plasmodium falciparum hexose transporter (PfHT), which mediates the uptake of D-glucose into parasites, is essential for survival of asexual blood-stage parasites. Recently, genetic studies in the rodent malaria model, Plasmodium berghei, found that the orthologous hexose transporter (PbHT) is expressed throughout the parasite's development within the mosquito vector, in addition to being essential durin...

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Publisher copy:
10.1128/aac.01739-10

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Journal:
Antimicrobial agents and chemotherapy
Volume:
55
Issue:
6
Pages:
2824-2830
Publication date:
2011-06-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:38586cc1-7303-41ac-b048-3cb460349a7d
Source identifiers:
268263
Local pid:
pubs:268263

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