- Abstract:
-
During blood infection, malarial parasites use D-glucose as their main energy source. The Plasmodium falciparum hexose transporter (PfHT), which mediates the uptake of D-glucose into parasites, is essential for survival of asexual blood-stage parasites. Recently, genetic studies in the rodent malaria model, Plasmodium berghei, found that the orthologous hexose transporter (PbHT) is expressed throughout the parasite's development within the mosquito vector, in addition to being essential durin...
Expand abstract - Publisher copy:
- 10.1128/aac.01739-10
-
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- Journal:
- Antimicrobial agents and chemotherapy
- Volume:
- 55
- Issue:
- 6
- Pages:
- 2824-2830
- Publication date:
- 2011-06-05
- DOI:
- EISSN:
-
1098-6596
- ISSN:
-
0066-4804
- URN:
-
uuid:38586cc1-7303-41ac-b048-3cb460349a7d
- Source identifiers:
-
268263
- Local pid:
- pubs:268263
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle.
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