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Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells

Abstract:

We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase. Overexpression of centromeric mouse minor satellite also increased chromosome instability in the murine stem but not in human cells. Analysis of chromosome segregation in vivo showed disturbances ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1155/2017/7506976

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Human Genetics Wt Centre
Oxford college:
St Johns College
Role:
Author
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Role:
Author
ORCID:
0000-0002-4917-8403
Publisher:
Hindawi Publisher's website
Journal:
Disease Markers Journal website
Volume:
2017
Pages:
ART: 7506976
Publication date:
2017-07-11
Acceptance date:
2017-06-04
DOI:
EISSN:
1875-8630
ISSN:
0278-0240
Pubs id:
pubs:713321
URN:
uri:3857fb93-2f00-440c-908d-88355f4f91cc
UUID:
uuid:3857fb93-2f00-440c-908d-88355f4f91cc
Local pid:
pubs:713321

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