Journal article
Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells
- Abstract:
-
We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase. Overexpression of centromeric mouse minor satellite also increased chromosome instability in the murine stem but not in human cells. Analysis of chromosome segregation in vivo showed disturbances ...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 1.8MB)
-
- Publisher copy:
- 10.1155/2017/7506976
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
- Publisher:
- Hindawi Publisher's website
- Journal:
- Disease Markers Journal website
- Volume:
- 2017
- Pages:
- ART: 7506976
- Publication date:
- 2017-07-11
- Acceptance date:
- 2017-06-04
- DOI:
- EISSN:
-
1875-8630
- ISSN:
-
0278-0240
- Pmid:
-
28781416
- Source identifiers:
-
713321
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:713321
- UUID:
-
uuid:3857fb93-2f00-440c-908d-88355f4f91cc
- Local pid:
- pubs:713321
- Deposit date:
- 2019-03-28
Terms of use
- Copyright holder:
- Chan et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 David Y. L. Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record