- Abstract:
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We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase. Overexpression of centromeric mouse minor satellite also increased chromosome instability in the murine stem but not in human cells. Analysis of chromosome segregation in vivo showed disturbances ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 1.8MB)
-
- Publisher copy:
- 10.1155/2017/7506976
-
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- Publisher:
- Hindawi Publisher's website
- Journal:
- Disease Markers Journal website
- Volume:
- 2017
- Pages:
- ART: 7506976
- Publication date:
- 2017-07-11
- Acceptance date:
- 2017-06-04
- DOI:
- EISSN:
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1875-8630
- ISSN:
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0278-0240
- Pubs id:
-
pubs:713321
- URN:
-
uri:3857fb93-2f00-440c-908d-88355f4f91cc
- UUID:
-
uuid:3857fb93-2f00-440c-908d-88355f4f91cc
- Local pid:
- pubs:713321
- Language:
- English
- Keywords:
- Copyright holder:
- Chan et al.
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 David Y. L. Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells
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