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Noncoding Centromeric RNA Expression Impairs Chromosome Stability in Human and Murine Stem Cells

Abstract:

We analyzed the effect of transcribed noncoding RNA centromeric satellites on chromosome segregation in normal human and murine stem and fibrosarcoma cells. The overexpression of different centromeric alphoid DNAs in all cell lines induced a marked increase in chromosome mis-segregation in anaphase. Overexpression of centromeric mouse minor satellite also increased chromosome instability in the murine stem but not in human cells. Analysis of chromosome segregation in vivo showed disturbances ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1155/2017/7506976

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Oxford college:
St John's College
Role:
Author
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Role:
Author
ORCID:
0000-0002-4917-8403
Publisher:
Hindawi Publisher's website
Journal:
Disease Markers Journal website
Volume:
2017
Pages:
ART: 7506976
Publication date:
2017-07-11
Acceptance date:
2017-06-04
DOI:
EISSN:
1875-8630
ISSN:
0278-0240
Pmid:
28781416
Source identifiers:
713321
Language:
English
Keywords:
Pubs id:
pubs:713321
UUID:
uuid:3857fb93-2f00-440c-908d-88355f4f91cc
Local pid:
pubs:713321
Deposit date:
2019-03-28

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