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Journal article

Susceptibility to sequelae of human ocular chlamydial infection associated with allelic variation in IL10 cis-regulation.

Abstract:

Trachoma, an infectious disease of the conjunctiva caused by Chlamydia trachomatis, causes scarring and blindness in some infected individuals but not others. In an African community where trachoma is endemic, we have previously identified an IL10 haplotype that is associated with increased risk of scarring complications. Here we examine the hypothesis that the risk haplotype (H-RISK) affects levels of IL10 expression in the conjunctiva during active trachoma infection. To overcome potential ...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddm310

Authors


Natividad, A More by this author
Holland, MJ More by this author
Rockett, KA More by this author
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Journal:
Human molecular genetics
Volume:
17
Issue:
2
Pages:
323-329
Publication date:
2008-01-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:382fd568-3414-46a5-bcc6-72a921ed2df2
Source identifiers:
40627
Local pid:
pubs:40627

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