Journal article
Risk of hand osteoarthritis in new users of hormone replacement therapy: a nested case-control analysis
- Abstract:
-
Objective
To estimate the risk of hand osteoarthritis (HOA) associated with hormone replacement therapy (HRT).
Methods
We conducted a nested case-control study using data from the UKbased Clinical Practice Research Datalink (1998–2017). In the study inception cohort comprised women at age 45. We matched women with incident HOA during follow-up (cases) to osteoarthritisfree controls on age and calendar date (index date, ID), in a ratio of 1:4. We applied conditional logistic regression to calculate odds ratios (OR) with 95 % confidence intervals (CI) of HOA associated with new HRT use compared with non-use overall, and for women with recorded menopause we calculated separate ORs according to the time between menopause and HRT initiation (current users), and the time between HRT cessation and the ID (past users), versus non-users.
Results
There were 3440 cases and 13,760 controls (mean age: 50.9 ± 4.1 years). We observed an adjusted OR (aOR) of HOA of 1.32 (95 % CI 1.17–1.48) in HRT users (versus nonusers), which attenuated to 0.98 (95 % CI 0.85–1.14) in women with recorded menopause. Current users (versus nonusers) who initiated HRT 3 months before or after menopause had an aOR of 0.72 (95 % CI 0.55–0.96), while aORs increased with later HRT initiation. Among past users (versus non-users), we observed an aOR of 1.25 (95 % CI 0.86–1.81) when HRT use was stopped ≤18 months before the ID, approaching the null with increasing duration between HRT cessation and the ID.
Conclusion
Current HRT use was associated with a decreased risk of HOA if initiated around menopause, but the risk reduction disappeared after HRT cessation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 829.5KB, Terms of use)
-
- Publisher copy:
- 10.1016/j.maturitas.2019.11.006
Authors
- Publisher:
- Elsevier
- Journal:
- Maturitas More from this journal
- Volume:
- 132
- Pages:
- 17-23
- Publication date:
- 2019-11-27
- Acceptance date:
- 2019-11-26
- DOI:
- EISSN:
-
01873-4111
- ISSN:
-
0378-5122
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:1074464
- UUID:
-
uuid:382f45a9-15e3-4769-82a8-7ca15836fca4
- Local pid:
-
pubs:1074464
- Source identifiers:
-
1074464
- Deposit date:
-
2019-11-27
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier B.V.
- Copyright date:
- 2019
- Rights statement:
- © 2019 Elsevier B.V. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.maturitas.2019.11.006
If you are the owner of this record, you can report an update to it here: Report update to this record