Journal article
Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody
- Abstract:
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G protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors targeted by therapeutics. Their diverse signalling capabilities lead to involvement in a wide range of physiological and disease responses. The vast majority of molecules currently available to target GPCRs are designed to act at the binding site (the orthosteric site) for endogenous ligands, either promoting receptor signalling as agonists, or inhibiting as antagonists. However, a continuing challenge ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.8MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-023-39310-x
Authors
- Publisher:
- Nature Research
- Journal:
- Nature Communications More from this journal
- Volume:
- 14
- Issue:
- 1
- Pages:
- 3655-3655
- Publication date:
- 2023-06-20
- DOI:
- EISSN:
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2041-1723
- ISSN:
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2041-1723
- Language:
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English
- Keywords:
- Pubs id:
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2364930
- Local pid:
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pubs:2364930
- Source identifiers:
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W4381433681
- Deposit date:
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2026-01-30
- ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.
Terms of use
- Copyright date:
- 2023
- Licence:
- CC Attribution (CC BY)
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