Induction of simian immunodeficiency virus (SIV)-specific CTL in rhesus macaques by vaccination with modified vaccinia virus Ankara expressing SIV transgenes: influence of pre-existing anti-vector immunity.

Journal article

A major aim in AIDS vaccine development is the definition of strategies to stimulate strong and durable cytotoxic T lymphocyte (CTL) responses. Here we report that simian immunodeficiency virus (SIV)-specific CTL developed in 4/4 macaques following a single intramuscular injection of modified vaccinia virus Ankara (MVA) constructs expressing both structural and regulatory/accessory genes of SIV. In two animals Nef-specific responses persisted, but other responses diminished and new responses ...

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Authors: Sharpe, S; Polyanskaya, N; Dennis, M; Sutter, G; Hanke, T

• Publication status: Published
• Journal: Journal of general virology
• Volume: 82
• Issue: Pt 9
• Pages: 2215-2223
• Publication date: 2001-09-01
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English
• Keywords: Vaccinia virus; Gene Products, gag; Transgenes; T-Lymphocytes, Cytotoxic; Simian immunodeficiency virus; Fusion Proteins, gag-pol; Vaccination; Genetic Vectors; Animals; Macaca mulatta