Journal article
Combined nucleobase and backbone modifications enhance DNA duplex stability and preserve biocompatibility
- Abstract:
-
DNA strands containing a triazole linkage flanked on its 3′-side by an aminoethylphenoxazine nucleobase analogue (G-clamp) have been prepared by solid-phase synthesis followed by CuAAC-mediated click oligonucleotide ligation. The stability of the doubly modified DNA duplexes and DNA-RNA hybrids is greatly increased, whereas a single base pair mismatch located at or adjacent to the modifications is strongly destabilising, making triazole G-clamp a potent mismatch/point mutation sensor. A DNA s...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Grant:
BB/
J001694/1 “Extending the boundaries of nucleic acid
chemistry.”
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Chemical Science Journal website
- Volume:
- 5
- Issue:
- 1
- Pages:
- 253-259
- Publication date:
- 2014-01-01
- Acceptance date:
- 2013-10-14
- DOI:
- EISSN:
-
2041-6539
- ISSN:
-
2041-6520
Item Description
- Pubs id:
-
pubs:443633
- UUID:
-
uuid:380686fb-d3a2-4de7-aa21-ae8af12d9928
- Local pid:
- pubs:443633
- Source identifiers:
-
443633
- Deposit date:
- 2016-03-01
Terms of use
- Copyright holder:
- El-Sagheer and Brown
- Copyright date:
- 2014
- Notes:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record