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Journal article

Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.

Abstract:

BACKGROUND: Endothelial cell (EC) survival and regeneration are important determinants of the response to vascular injury that leads to neointimal hyperplasia and accelerated atherosclerosis. Nitric oxide (NO) is a key regulator of EC and endothelial progenitor cell function, but the pathophysiological mechanisms that regulate endothelial NO synthase in endothelial regeneration remain unclear. METHODS AND RESULTS: Endothelium-targeted overexpression of GTP cyclohydrolase (GCH) I increased lev...

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Publication status:
Published

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Journal:
Circulation
Volume:
128
Issue:
11 Suppl 1
Pages:
S50-S58
Publication date:
2013-09-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
429649
Language:
English
Keywords:
Pubs id:
pubs:429649
UUID:
uuid:3802d7b1-26d2-4601-b2a0-baf612ccfed9
Local pid:
pubs:429649
Deposit date:
2013-11-16

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