Journal article
Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
- Abstract:
-
BACKGROUND: Endothelial cell (EC) survival and regeneration are important determinants of the response to vascular injury that leads to neointimal hyperplasia and accelerated atherosclerosis. Nitric oxide (NO) is a key regulator of EC and endothelial progenitor cell function, but the pathophysiological mechanisms that regulate endothelial NO synthase in endothelial regeneration remain unclear. METHODS AND RESULTS: Endothelium-targeted overexpression of GTP cyclohydrolase (GCH) I increased lev...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/circulationaha.112.000249
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Authors
Bibliographic Details
- Journal:
- Circulation
- Volume:
- 128
- Issue:
- 11 Suppl 1
- Pages:
- S50-S58
- Publication date:
- 2013-09-01
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- Source identifiers:
-
429649
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:429649
- UUID:
-
uuid:3802d7b1-26d2-4601-b2a0-baf612ccfed9
- Local pid:
- pubs:429649
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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