- Abstract:
-
The potential importance of HLA-C-restricted CD8+ cytotoxic T lymphocytes (CTL) in HIV infection remains undetermined. We studied the dominant HLA-Cw*03-restricted CTL response to YVDRFFKTL(296-304) (YL9), within the conserved major homology region (MHR) of the Gag protein, in 80 HLA-Cw*03-positive individuals with chronic HIV infection to better define the efficacy of the YL9 HLA-C-restricted response. The HLA-Cw*03 allele is strongly associated with HIV sequence changes from Thr-303 to Val,...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.01144-10
-
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- Journal:
- Journal of virology
- Volume:
- 84
- Issue:
- 21
- Pages:
- 11279-11288
- Publication date:
- 2010-11-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:37fd1309-91fb-4e5b-99db-18ff7d1633da
- Source identifiers:
-
191244
- Local pid:
- pubs:191244
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation.
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