Journal article icon

Journal article

The major transition state in folding need not involve the immobilization of side chains.

Abstract:

During protein folding in which few, if any, definable kinetic intermediates are observable, the nature of the transition state is central to understanding the course of the reaction. Current experimental data does not distinguish the relative contributions of side chain immobilization and dehydration phenomena to the major rate-limiting transition state whereas this distinction is central to theoretical models that attempt to simulate the behavior of proteins during folding. Renaturation of ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.97.11.5790

Authors


Staniforth, RA More by this author
Zerovnik, E More by this author
Clarke, AR More by this author
Expand authors...
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
11
Pages:
5790-5795
Publication date:
2000-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:37e5672d-1e97-47b8-84eb-8b11379dbb86
Source identifiers:
224867
Local pid:
pubs:224867

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP