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Journal article

The major transition state in folding need not involve the immobilization of side chains.

Abstract:

During protein folding in which few, if any, definable kinetic intermediates are observable, the nature of the transition state is central to understanding the course of the reaction. Current experimental data does not distinguish the relative contributions of side chain immobilization and dehydration phenomena to the major rate-limiting transition state whereas this distinction is central to theoretical models that attempt to simulate the behavior of proteins during folding. Renaturation of ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.97.11.5790

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
11
Pages:
5790-5795
Publication date:
2000-05-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
224867
Language:
English
Keywords:
Pubs id:
pubs:224867
UUID:
uuid:37e5672d-1e97-47b8-84eb-8b11379dbb86
Local pid:
pubs:224867
Deposit date:
2013-11-16

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