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Journal article

Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6

Abstract:

Ly6/urokinase‐type plasminogen activator receptor (uPAR) (LU) domain containing 6 (LYPD6) is a Wnt signaling enhancer that promotes phosphorylation of the Wnt coreceptor low density lipoprotein receptor‐related protein 6 (LRP6). It also binds the nicotinic acetylcholine receptor (nAChR). We report here the 1.25 Å resolution structure of the LYPD6 extracellular LU domain and map its interaction with LRP6 by mutagenesis and surface plasmon resonance. The LYPD6LU structure reveals a ‘trifingered...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/1873-3468.13212

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0001-8916-8552
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More from this funder
Funding agency for:
Jones, EY
Grant:
MR/M000141/1
More from this funder
Funding agency for:
Jones, EY
Grant:
MR/M000141/1
Publisher:
Wiley Publisher's website
Journal:
FEBS Letters Journal website
Volume:
592
Issue:
18
Pages:
3152-3162
Publication date:
2018-08-01
Acceptance date:
2018-07-27
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Source identifiers:
904447
Keywords:
Pubs id:
pubs:904447
UUID:
uuid:379c771d-9622-481f-a22f-275819005759
Local pid:
pubs:904447
Deposit date:
2018-08-10

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