Journal article
Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6
- Abstract:
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Ly6/urokinase‐type plasminogen activator receptor (uPAR) (LU) domain containing 6 (LYPD6) is a Wnt signaling enhancer that promotes phosphorylation of the Wnt coreceptor low density lipoprotein receptor‐related protein 6 (LRP6). It also binds the nicotinic acetylcholine receptor (nAChR). We report here the 1.25 Å resolution structure of the LYPD6 extracellular LU domain and map its interaction with LRP6 by mutagenesis and surface plasmon resonance. The LYPD6LU structure reveals a ‘trifingered...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 1.5MB)
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- Publisher copy:
- 10.1002/1873-3468.13212
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Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- FEBS Letters Journal website
- Volume:
- 592
- Issue:
- 18
- Pages:
- 3152-3162
- Publication date:
- 2018-08-01
- Acceptance date:
- 2018-07-27
- DOI:
- EISSN:
-
1873-3468
- ISSN:
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0014-5793
- Source identifiers:
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904447
Item Description
- Keywords:
- Pubs id:
-
pubs:904447
- UUID:
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uuid:379c771d-9622-481f-a22f-275819005759
- Local pid:
- pubs:904447
- Deposit date:
- 2018-08-10
Terms of use
- Copyright holder:
- Crown copyright
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Crown copyright. FEBS Letters © 2018 Federation of European Biochemical Societies. This is the accepted manuscript version of the article. The final version is available online from Wiley at: https://doi.org/10.1002/1873-3468.13212
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