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Journal article

Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity.

Abstract:

Serine proteases in the adult CNS contribute both to activity-dependent structural changes accompanying learning and to the regulation of excitotoxic cell death. Brain serine protease 1 (BSP1)/neuropsin is a trypsin-like serine protease exclusively expressed, within the CNS, in the hippocampus and associated limbic structures. To explore the role of this enzyme, we have used gene targeting to disrupt this gene in mice. Mutant mice were viable and overtly normal; they displayed normal hippocam...

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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
21
Issue:
18
Pages:
6993-7000
Publication date:
2001-09-05
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:37945e45-335b-4034-ad43-eef42cac4a31
Source identifiers:
95855
Local pid:
pubs:95855

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