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Exploring the roles of protein kinases using chemical genetics

Abstract:

The protein kinase superfamily is one of the most important families of enzymes in molecular biology. Protein kinases typically catalyze the transfer of the -phosphate from ATP to a protein substrate (a highly ubiquitous cellular reaction), thereby controlling key areas of cell regulation. Deregulation of protein kinases is known to contribute to many human diseases, and selective inhibitors of protein kinases are a major area of interest in medicinal chemistry. However, a detailed understand...

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Publisher copy:
10.4155/fmc.09.50

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Journal:
Future Medicinal Chemistry
Volume:
1
Issue:
7
Pages:
1233-1241
Publication date:
2009-10-05
DOI:
ISSN:
1756-8919
URN:
uuid:378bd225-fed9-4eb9-9b83-18f7ff108cee
Source identifiers:
134419
Local pid:
pubs:134419
Language:
English

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