Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

Journal article

Understanding cancer pathogenesis requires knowledge of not only the specific contributory genetic mutations but also the cellular framework in which they arise and function. Here we explore the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is characterized by a chromosomal translocation generating a TEL-AML1 fusion gene. We identify a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. By studying a monocho...

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Authors: Hong, D; Gupta, R; Ancliff, P; Atzberger, A; Brown, J

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 319
• Issue: 5861
• Pages: 336-339
• Publication date: 2008-01-01
• DOI: 10.1126/science.1150648
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Oncogene Proteins, Fusion; Mice, SCID; Core Binding Factor Alpha 2 Subunit; Transplantation, Heterologous; Humans; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Twins, Monozygotic; Apoptosis; Neoplastic Stem Cells; Fetal Blood; Diseases in Twins; Bone Marrow Transplantation; Precursor Cells, B-Lymphoid; Neoplasm Transplantation; Preleukemia; Acute Disease; Animals; Antigens, CD34; Male; Recombination, Genetic; Antigens, CD38; Female; Antigens, CD19; Child, Preschool; Mice, Inbred NOD; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Mice