A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.

Journal article

We have isolated two genes, Hox-2.8 and Hox-2.9, from the mouse homeobox cluster Hox-2, located on chromosome 11. A 120-kilobase yeast artificial chromosome (YAC) containing a large region of the murine Hox-2 cluster, including 45 kilobases of sequence upstream of the most 5' gene, was cloned. The DNA sequence of the YAC is unrearranged relative to the genomic map. We have subcloned from the YAC insert a homeobox gene, Hox-2.8, whose homeodolmain is highly related to that of the Drosophila ho...

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Authors: Rubock, M; Larin, Z; Cook, M; Papalopulu, N; Krumlauf, R

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 87
• Issue: 12
• Pages: 4751-4755
• Publication date: 1990-06-01
• DOI: 10.1073/pnas.87.12.4751
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Base Sequence; Sequence Homology, Nucleic Acid; Multigene Family; Chromosomes, Fungal; RNA Probes; Molecular Sequence Data; Animals; Saccharomyces cerevisiae; Genes, Homeobox; Restriction Mapping; Cloning, Molecular; Chromosome Mapping; Oligonucleotide Probes; Mice; Amino Acid Sequence