Journal article icon

Journal article

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.

Abstract:

Many protein kinases are activated by a conserved regulatory step involving T-loop phosphorylation. Although there is considerable focus on kinase activator proteins, the importance of specific T-loop phosphatases reversing kinase activation has been underappreciated. We find that the protein phosphatase 6 (PP6) holoenzyme is the major T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of PP6 function by depletion of catalytic or regulatory subunits interferes with spindle for...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1083/jcb.201008106

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
The Journal of cell biology
Volume:
191
Issue:
7
Pages:
1315-1332
Publication date:
2010-12-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:3747f40d-a544-4a60-ae55-dade5bb2b8df
Source identifiers:
196736
Local pid:
pubs:196736

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP