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Homocysteine and vascular disease: Review of published results of the homocysteine-lowering trials

Abstract:

Moderately elevated homocysteine levels have been associated with a higher risk of cardiovascular disease in observational studies, but whether these associations are causal is uncertain. Randomized trials of dietary supplementation with B vitamins were set up to assess whether lowering homocysteine levels could reduce the risk of vascular disease. This review is based on a meta-analysis of published results of eight homocysteine-lowering trials for preventing vascular disease. The eight tria...

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Publisher copy:
10.1007/s10545-010-9235-y

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Journal:
Journal of Inherited Metabolic Disease
Volume:
34
Issue:
1
Pages:
83-91
Publication date:
2011-02-01
DOI:
EISSN:
1573-2665
ISSN:
0141-8955
Language:
English
Pubs id:
pubs:149892
UUID:
uuid:3740a137-3f8d-4dfc-aacc-dd6ea580968b
Local pid:
pubs:149892
Source identifiers:
149892
Deposit date:
2012-12-19

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