Journal article
Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits.
- Abstract:
-
Mouse-adapted scrapie strains have been characterized by vacuolation profiles and incubation times, but the behavioral consequences have not been well studied. Here, we compared behavioral impairments produced by ME7, 79A, 22L, and 22A strains in C57BL/6J mice. We show that early impairments on burrowing, glucose consumption, nesting and open field activity, and late stage motor impairments show a very similar temporal sequence in ME7, 79A, and 22L. The long incubation time of the 22A strain ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Neurobiology of disease
- Volume:
- 18
- Issue:
- 2
- Pages:
- 258-269
- Publication date:
- 2005-03-01
- DOI:
- EISSN:
-
1095-953X
- ISSN:
-
0969-9961
- Source identifiers:
-
280499
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:280499
- UUID:
-
uuid:37321c3f-cec1-4cc5-94df-7208348c8a86
- Local pid:
- pubs:280499
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2005
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