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Journal article

Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits.

Abstract:

Mouse-adapted scrapie strains have been characterized by vacuolation profiles and incubation times, but the behavioral consequences have not been well studied. Here, we compared behavioral impairments produced by ME7, 79A, 22L, and 22A strains in C57BL/6J mice. We show that early impairments on burrowing, glucose consumption, nesting and open field activity, and late stage motor impairments show a very similar temporal sequence in ME7, 79A, and 22L. The long incubation time of the 22A strain ...

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Publication status:
Published

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Publisher copy:
10.1016/j.nbd.2004.08.015

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Neurobiology of disease
Volume:
18
Issue:
2
Pages:
258-269
Publication date:
2005-03-05
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
URN:
uuid:37321c3f-cec1-4cc5-94df-7208348c8a86
Source identifiers:
280499
Local pid:
pubs:280499

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