The 5' leader of the mRNA encoding the marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties.

Journal article

We demonstrate the presence of a functional internal ribosome entry site (IRES) within the 5' leader (designated 5L) from a variant of bicistronic mRNAs that encode the pp14 and RLORF9 proteins from Marek's disease virus (MDV) serotype 1. Transcribed as a 1.8-kb family of immediate-early genes, the mature bicistronic mRNAs have variable 5' leader sequences due to alternative splicing or promoter usage. Consequently, the presence or absence of the 5L IRES in the mRNA dictates the mode of pp14 ...

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Authors: Tahiri-Alaoui, A; Matsuda, D; Xu, H; Panagiotis, P; Burman, L

• Publication status: Published
• Journal: Journal of virology
• Volume: 83
• Issue: 24
• Pages: 12769-12778
• Publication date: 2009-12-01
• DOI: 10.1128/jvi.01010-09
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Animals; Ribosomes; Cells, Cultured; Codon; Herpesvirus 2, Gallid; RNA Caps; Genes; Allosteric Regulation; Viral Proteins; 5' Untranslated Regions; RNA, Messenger; Introns