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Microarray-CGH for the assessment of aneuploidy in human polar bodies and oocytes.

Abstract:

The cytogenetic analysis of single cells, such as oocytes and polar bodies, is extremely challenging. The main problem is low probability of obtaining a metaphase preparation in which all of the chromosomes are sufficiently well spread to permit accurate analysis (no overlapping chromosomes, no chromosomes lost). As a result, a high proportion of the oocytes subjected to cytogenetic analysis are not suitable for traditional chromosome banding studies or for molecular cytogenetic methods such ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Role:
Author
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
957
Pages:
267-283
Publication date:
2013-01-01
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:372075d1-783a-4405-b905-848ed6b34941
Source identifiers:
369940
Local pid:
pubs:369940

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