Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition.

Boitel, B; Ermonval, M; Panina-Bordignon, P; Mariuzza, R; Lanzavecchia, A; Acuto, O

Journal article

Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition.

Abstract:: To investigate the structural and genetic basis of the T cell response to defined peptide/major histocompatibility (MHC) class II complexes in humans, we established a large panel of T cell clones (61) from donors of different HLA-DR haplotypes and reactive with a tetanus toxin-derived peptide (tt830-844) recognized in association with most DR molecules (universal peptide). By using a bacterial enterotoxin-based proliferation assay and cDNA sequencing, we found preferential use of a particula...
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Publication status:: Published

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APA Style

Boitel, B., Ermonval, M., Panina-Bordignon, P., Mariuzza, R., Lanzavecchia, A., & Acuto, O. (1992). Preferential V beta gene usage and lack of junctional sequence conservation among human T cell receptors specific for a tetanus toxin-derived peptide: evidence for a dominant role of a germline-encoded V region in antigen/major histocompatibility complex recognition. Journal of Experimental Medicine, 175(3), 765–777.

MLA Style

Boitel, B., et al. “Preferential V Beta Gene Usage and Lack of Junctional Sequence Conservation among Human T Cell Receptors Specific for a Tetanus Toxin-Derived Peptide: Evidence for a Dominant Role of a Germline-Encoded V Region in Antigen/Major Histocompatibility Complex Recognition.” Journal of Experimental Medicine, vol. 175, no. 3, 1992, pp. 765–77.

Chicago Style

Boitel, B, M Ermonval, P Panina-Bordignon, R Mariuzza, A Lanzavecchia, and O Acuto. 1992. “Preferential V Beta Gene Usage and Lack of Junctional Sequence Conservation among Human T Cell Receptors Specific for a Tetanus Toxin-Derived Peptide: Evidence for a Dominant Role of a Germline-Encoded V Region in Antigen/Major Histocompatibility Complex Recognition.” Journal of Experimental Medicine 175 (3): 765–77.
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