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Journal article

Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals.

Abstract:

HIV-1 provirus, either as a chromosomal integrant or as an episomal plasmid in HeLa cells, forms a transcription-dependent gene loop structure between the 5'LTR promoter and 3'LTR poly(A) signal. Flavopiridol-mediated inhibition of RNA polymerase II elongation blocks 5' to 3'LTR juxtaposition, indicating that this structure is maintained during transcription. Analysis of mutant or hybrid HIV-1 plasmids demonstrates that replacement of the 5'LTR promoter with CMV or the 3'LTR poly(A) signal wi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Molecular cell
Volume:
29
Issue:
1
Pages:
56-68
Publication date:
2008-01-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:37045436-0959-4cf1-8782-fa8177e671a6
Source identifiers:
7561
Local pid:
pubs:7561

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