- Abstract:
-
HIV-1 provirus, either as a chromosomal integrant or as an episomal plasmid in HeLa cells, forms a transcription-dependent gene loop structure between the 5'LTR promoter and 3'LTR poly(A) signal. Flavopiridol-mediated inhibition of RNA polymerase II elongation blocks 5' to 3'LTR juxtaposition, indicating that this structure is maintained during transcription. Analysis of mutant or hybrid HIV-1 plasmids demonstrates that replacement of the 5'LTR promoter with CMV or the 3'LTR poly(A) signal wi...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.molcel.2007.11.030
-
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- Journal:
- Molecular cell
- Volume:
- 29
- Issue:
- 1
- Pages:
- 56-68
- Publication date:
- 2008-01-05
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- URN:
-
uuid:37045436-0959-4cf1-8782-fa8177e671a6
- Source identifiers:
-
7561
- Local pid:
- pubs:7561
- Language:
- English
- Keywords:
- Copyright date:
- 2008
Journal article
Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals.
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