The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look.

Journal article

The p38 mitogen-activated protein kinase (MAPK) signaling pathway has been strongly implicated in many of the processes that underlie the pathology of rheumatoid arthritis (RA). For many years it has been considered a promising target for development of new anti-inflammatory drugs with which to treat RA and other chronic immune-mediated inflammatory diseases. However, several recent clinical trials have concluded in a disappointing manner. Why is this so, if p38 MAPK clearly contributes to th...

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Authors: Clark, A; Dean, J

• Journal: open rheumatology journal
• Volume: 6
• Issue: SPEC. ISSUE 2
• Pages: 209-219
• Publication date: 2012-01-01
• DOI: 10.2174/1874312901206010209
• EISSN: 1874-3129
• ISSN: 1874-3129
• Language: English
• Keywords: Phosphorylation; Gene expression; Listeria monocytogenes; P38 MAPK; Inflammatory mediators