A sequence-ready map of the human chromosome 17p telomere.

Journal article

A half-YAC clone derived from human chromosome 17p was mapped at high resolution using cosmid subclone fingerprint analysis. Colinearity of the half-YAC with the telomeric human genomic DNA fragment was ascertained by RecA-assisted restriction endonuclease cleavage mapping. Previously isolated and radiation hybrid-mapped markers TEL17P37, TEL17P49, and TEL17P80 mapped 30-60 kb from the 17p terminus. This sequence-ready map permits high-resolution integration of genetic maps with the DNA seque...

Expand abstract

Authors: Xiang, Z; Hu, X; Flint, J; Riethman, H

• Publication status: Published
• Journal: Genomics
• Volume: 58
• Issue: 2
• Pages: 207-210
• Publication date: 1999-06-01
• DOI: 10.1006/geno.1999.5826
• EISSN: 1089-8646
• ISSN: 0888-7543
• Language: English
• Keywords: Cosmids; Endonucleases; Rec A Recombinases; Models, Genetic; Humans; Telomere; Chromosome Mapping; Molecular Sequence Data; Contig Mapping; Chromosomes, Human, Pair 17; Chromosomes, Artificial, Yeast