Journal article
Germinal centers: programmed for affinity maturation and antibody diversification
- Abstract:
- The seminal discovery by Eisen that antibodies undergo improvements in antigen-binding affinity over the course of an immune response led to a long running search for the underlying mechanism. Germinal centers in lymphoid organs are now recognized to be critically involved in this phenomenon, known as antibody affinity maturation. As well as improving in affinity for specific epitopes, some antibody responses maintain or even increase their breadth of antigen-recognition over time. This has led to another intense line of research aimed at understanding how broadly neutralizing anti-pathogen responses are generated. Recent work indicates that germinal centers also play an important role in the diversification process. We discuss current understanding of how germinal centers are programmed to support both affinity maturation and antibody diversification.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 252.5KB, Terms of use)
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- Publisher copy:
- 10.1016/j.coi.2016.12.004
Authors
- Publisher:
- Elsevier
- Journal:
- Current Opinion in Immunology More from this journal
- Volume:
- 45
- Pages:
- 21-30
- Publication date:
- 2017-01-12
- DOI:
- EISSN:
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1879-0372
- ISSN:
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0952-7915
- Language:
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English
- Keywords:
- Pubs id:
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pubs:671537
- UUID:
-
uuid:36f439fc-d017-494f-b077-83cf66eec0e2
- Local pid:
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pubs:671537
- Source identifiers:
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671537
- Deposit date:
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2017-02-20
- ARK identifier:
Terms of use
- Copyright holder:
- © 2017 Elsevier Ltd All rights reserved
- Copyright date:
- 2017
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from Elsevier at: 10.1016/j.coi.2016.12.004
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