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Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.

Abstract:

Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxyg...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Current opinion in structural biology
Volume:
9
Issue:
6
Pages:
722-731
Publication date:
1999-12-01
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
Source identifiers:
31593
Language:
English
Keywords:
Pubs id:
pubs:31593
UUID:
uuid:36e6d5b2-4316-43ff-be9b-1b79490553dd
Local pid:
pubs:31593
Deposit date:
2012-12-19

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