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Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.

Abstract:

Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxyg...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Current opinion in structural biology
Volume:
9
Issue:
6
Pages:
722-731
Publication date:
1999-12-05
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
URN:
uuid:36e6d5b2-4316-43ff-be9b-1b79490553dd
Source identifiers:
31593
Local pid:
pubs:31593

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