Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.

Journal article

Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxyg...

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Authors: Schofield, C; Zhang, Z

• Publication status: Published
• Journal: Current opinion in structural biology
• Volume: 9
• Issue: 6
• Pages: 722-731
• Publication date: 1999-12-01
• DOI: 10.1016/s0959-440x(99)00036-6
• EISSN: 1879-033X
• ISSN: 0959-440X
• Language: English
• Keywords: Amino Acid Oxidoreductases; Oxygenases; Catalysis; Ketoglutaric Acids; Protein Conformation; Models, Molecular; Oxidoreductases; Substrate Specificity