Journal article
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- Abstract:
-
Alpha synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the nervous system. We have demonstrated that exosomes released from alpha synuclein over-expressing SH-SY5Y cells contained alpha synuclein and these exosomes were capable of efficiently transferring alpha synuclein protein to normal SH-SY5Y cells. M...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Department of Health
More from this funder
Parkinson's Disease UK
More from this funder
Wellcome/MRC Parkinson's Disease Consortium
More from this funder
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Neurobiology of Disease Journal website
- Volume:
- 42
- Issue:
- 3
- Pages:
- 360-367
- Publication date:
- 2011-06-01
- DOI:
- ISSN:
-
0969-9961
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:36e0b497-53ec-4daf-bb00-70f1a6d43d05
- Local pid:
- ora:5822
- Deposit date:
- 2011-10-26
Related Items
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2011
- Notes:
- The full-text of this article is not available in ORA, but you may be able to access the article via the publisher copy link on this record page.
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record