Journal article
Regulation of actin nucleation and autophagosome formation
- Abstract:
- Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1007/s00018-016-2224-z
Authors
+ Cancer Research UK
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- Funder identifier:
- https://ror.org/054225q67
- Grant:
- C300/A13058
+ Medical Research Council
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- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- G1000807
- Publisher:
- Springer
- Journal:
- Cellular and Molecular Life Sciences More from this journal
- Volume:
- 73
- Issue:
- 17
- Pages:
- 3249-3263
- Publication date:
- 2016-05-04
- Acceptance date:
- 2016-04-08
- DOI:
- EISSN:
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1420-9071
- ISSN:
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1420-682X
- Pmid:
-
27147468
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:619933
- UUID:
-
uuid:36dcfb69-701a-420e-a727-cf1311056ab9
- Local pid:
-
pubs:619933
- Source identifiers:
-
619933
- Deposit date:
-
2018-03-09
- ARK identifier:
Terms of use
- Copyright holder:
- Coutts and La Thangue
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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