Journal article
Plasma cytokines and risk of coronary heart disease in the PROCARDIS study
- Abstract:
- Objective The aims of the study were to examine the associations of plasma levels of five cytokines (interleukin (IL)-6, IL-5, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 receptor (IL-6R)) and C reactive protein (CRP) with risk of coronary heart disease (CHD). Methods: In a case–control study of 931 CHD cases and 974 controls, logistic regression was used to estimate the OR and 95% CI of CHD for extreme thirds of biomarkers after adjustment for established risk factors. Sensitivity analyses were conducted in non-statin and in non-aspirin users. Results: Plasma levels of CRP were moderately correlated with IL-6 (r=0.45) in controls, but more weakly correlated with other cytokines. Likewise, all other cytokines were only weakly correlated with each other. After adjustment for established risk factors, the ORs (95% CI) for CHD comparing extreme thirds of cytokine levels (defined in controls) were 2.53 (1.86 to 3.43) for IL-6, 1.46 (1.11 to 1.93) for IL-5 and 1.46 (1.09 to 1.95) for IFN-γ, respectively. However, neither TNF-α, IL-6R nor CRP was significantly associated with CHD. After further adjustment for the associated cytokines, only IL-5 (1.34; 1.00 to 1.80) and IL-6 (2.39; 1.73 to 3.30) remained significantly associated with CHD. The risk associations of cytokines in non-users of statins or aspirin were comparable with the overall population. Conclusions: This study confirmed the importance of IL-6 as the most strongly associated cytokine with CHD risk, but also demonstrated novel and independent associations of IL-5 with CHD that warrant further investigation using larger panels of cytokines.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 849.7KB, Terms of use)
-
- Publisher copy:
- 10.1136/openhrt-2018-000807
Authors
+ British Heart Foundation
More from this funder
- Funding agency for:
- Hopewell, J
- Grant:
- FS/14/55/30806
- Publisher:
- BMJ Publishing Group
- Journal:
- Open Heart More from this journal
- Volume:
- 5
- Issue:
- 1
- Article number:
- e000807
- Publication date:
- 2018-04-25
- Acceptance date:
- 2018-04-04
- DOI:
- ISSN:
-
2053-3624
- Keywords:
- Pubs id:
-
pubs:835111
- UUID:
-
uuid:36dbce59-b78e-43c8-92a2-992a502c6a29
- Local pid:
-
pubs:835111
- Source identifiers:
-
835111
- Deposit date:
-
2018-04-11
Terms of use
- Copyright holder:
- Clarke et al
- Copyright date:
- 2018
- Notes:
- This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record