Journal article
Longitudinal analysis of myelin oligodendrocyte glycoprotein antibodies in CNS inflammatory diseases.
- Abstract:
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Background
We evaluated the seroprevalence of myelin oligodendrocyte glycoprotein immunoglobulin G1 (MOG-IgG) and associated clinical features of patients from a large adult-dominant unselected cohort with mainly relapsing central nervous system (CNS) inflammatory diseases. We also investigate the clinical relevance of MOG-IgG through a longitudinal analysis of serological status over a 2-year follow-up period.
Methods
Serum samples from 505 patients with CNS inflammatory diseases at the National Cancer Center were analysed using cell-based assays for MOG-IgG and aquaporin-4 immunoglobulin G (AQP4-IgG). MOG-IgG serostatus was longitudinally assessed in seropositive patients with available serum samples and at least 2 years follow-up.
Results
Twenty-two of 505 (4.4%) patients with CNS inflammatory diseases were positive for MOGIgG. Patients with MOG-IgG had neuromyelitis optica spectrum disorder (NMOSD, n=10), idiopathic AQP4-IgGnegative myelitis (n=4), idiopathic AQP4-IgG-negative optic neuritis (n=4), other demyelinating syndromes (n=3) and multiple sclerosis (n=1). No relapses were seen in patients when they became MOG-IgG seronegative, whereas a persistent positive serological status was observed in patients with clinical relapses despite immunotherapy.
Conclusions
In a large adult-predominant unselected cohort of mainly relapsing CNS inflammatory diseases, we confirmed that NMOSD phenotype was most commonly observed in patients with MOG-IgG. A longitudinal analysis with 2-year follow-up suggested that persistence of MOG-IgG is associated with relapses.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 454.7KB, Terms of use)
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- Publisher copy:
- 10.1136/jnnp-2017-315998
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- Journal of Neurology, Neurosurgery, and Psychiatry More from this journal
- Volume:
- 88
- Issue:
- 10
- Pages:
- 811-817
- Publication date:
- 2017-09-01
- Acceptance date:
- 2017-05-22
- DOI:
- EISSN:
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1468-330X
- ISSN:
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0022-3050
- Pmid:
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28684532
- Language:
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English
- Keywords:
- Pubs id:
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pubs:708064
- UUID:
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uuid:3674118c-d7d2-4342-8975-986c2a45b81e
- Local pid:
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pubs:708064
- Source identifiers:
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708064
- Deposit date:
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2017-09-26
Terms of use
- Copyright holder:
- Irani et al
- Copyright date:
- 2017
- Notes:
- © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
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