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Correlations between gene expression highlight a different activation of ACE/TLR4/PTGS2 signaling in symptomatic and asymptomatic plaques in atherosclerotic patients

Abstract:

Inflammation has a key role and translates the effects of many known risk factors for the disease in atherosclerotic vulnerable plaques. Aiming to look into the elements that induce the development of either a vulnerable or stable atherosclerotic plaque, and considering that inflammation has a central role in the progression of lesions, we analyzed the expression of genes involved in the ACE/TLR4/PTGS2 signaling in carotid plaques of symptomatic and asymptomatic patients. Patients with intern...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1007/s11033-018-4207-7

Authors


Ferronato, S More by this author
Alberto, S More by this author
Gomez-Lira, M More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Olivato, S More by this author
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Romanelli F.U.R. More from this funder
Turco F.U.R. More from this funder
Publisher:
Springer Publisher's website
Journal:
Molecular Biology Reports Journal website
Volume:
45
Issue:
4
Pages:
657–662
Publication date:
2018-06-19
Acceptance date:
2018-06-07
DOI:
EISSN:
1573-4978
ISSN:
0301-4851
Pubs id:
pubs:860583
URN:
uri:3671df3a-6c47-4ee5-8090-a0786100e7ad
UUID:
uuid:3671df3a-6c47-4ee5-8090-a0786100e7ad
Local pid:
pubs:860583

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