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Antibacterial barbituric acid analogues inspired from natural 3-acyltetramic acids; synthesis, tautomerism and structure and physicochemical property-antibacterial activity relationships.

Abstract:

The synthesis, tautomerism and antibacterial activity of novel barbiturates is reported. In particular, 3-acyl and 3-carboxamidobarbiturates exhibited antibacterial activity, against susceptible and some resistant Gram-positive strains of particular interest is that these systems possess amenable molecular weight, rotatable bonds and number of proton-donors/acceptors for drug design as well as less lipophilic character, with physicochemical properties and ionic states that are similar to curr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/molecules20033582

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Galapagos SASU More from this funder
Publisher:
MDPI Publisher's website
Journal:
Molecules (Basel, Switzerland) Journal website
Volume:
20
Issue:
3
Pages:
3582-3627
Publication date:
2015-01-01
DOI:
EISSN:
1420-3049
ISSN:
1420-3049
Source identifiers:
508385
Language:
English
Keywords:
Pubs id:
pubs:508385
UUID:
uuid:36529628-d859-4558-b266-43b937cdbbeb
Local pid:
pubs:508385
Deposit date:
2016-01-08

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