HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis.

Journal article

The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in highly exposed, persistently seronegative populations is unknown. In 1996-1997 we screened for CTL responses against HIV clade B Env in 39 recently enrolled Kenyan female sex workers, and followed these women prospectively. Annual HIV incidence was 5.8%. CTL were independently associated with age and recent HIV-1 exposure,but were not prospectively associated with protection in a multivariable model that included HIV-1 exposure and duration of sex work.

Authors: Kaul, R; Rutherford, J; Rowland-Jones, S; Kimani, J; Onyango, J

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 18
• Issue: 15
• Pages: 2087-2089
• Publication date: 2004-10-01
• DOI: 10.1097/00002030-200410210-00015
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: Prostitution; Cohort Studies; HIV Seronegativity; Humans; HIV-1; Immunity, Cellular; Genes, env; Female; Kenya; T-Lymphocytes, Cytotoxic; Prospective Studies; Adult