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Journal article

Immune phenotype and function of NK and T cells in chronic hepatitis C patients who received a single dose of anti-miR-122, RG-101.

Abstract:

MicroRNA-122 (miR-122) is an important host factor for the hepatitis C (HCV) virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic hepatitis C (CHC) infection. Here, we analyzed the effects of RG-101 therapy on antiviral immunity. 32 CHC patients HCV genotype 1, 3 and 4 received a single subcutaneous administration with RG-101 at 2 mg/kg (n=14), 4 mg/kg (n=14) or placebo (n=2 per dosing group). P...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/hep.29148

Authors


van der Ree, MH More by this author
Sinnige, MJ More by this author
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Funding agency for:
Klenerman, P
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Funding agency for:
Klenerman, P
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Funding agency for:
Klenerman, P
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Publisher:
Wiley Publisher's website
Journal:
Hepatology Journal website
Volume:
66
Issue:
1
Pages:
57–68
Publication date:
2017-03-05
Acceptance date:
2017-03-03
DOI:
ISSN:
1527-3350
Pubs id:
pubs:686131
URN:
uri:36413f7a-96c8-4f0f-92e5-e2802854e7c9
UUID:
uuid:36413f7a-96c8-4f0f-92e5-e2802854e7c9
Local pid:
pubs:686131

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