Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast.

Journal article

The elongation phase of transcription by RNA polymerase II (RNAPII) is highly regulated and tightly linked to pre-messenger RNA (pre-mRNA) processing. Recent studies have implicated an early elongation checkpoint that facilitates the link to pre-mRNA processing. Here we show that the yeast forkhead transcription factors, Fkh1p and Fkh2p, associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination. These events are coordinated w...

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Authors: Morillon, A; O'Sullivan, J; Azad, A; Proudfoot, N; Mellor, J

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 300
• Issue: 5618
• Pages: 492-495
• Publication date: 2003-04-01
• DOI: 10.1126/science.1081379
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Uracil; RNA Precursors; RNA, Messenger; Transcription, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Promoter Regions, Genetic; Phosphoprotein Phosphatases; Saccharomyces cerevisiae; Cell Cycle Proteins; Gene Expression Regulation, Fungal; RNA Polymerase II; Phosphoserine; Transcription Factors; Forkhead Transcription Factors; Genes, Fungal; Phosphorylation; RNA, Fungal; Cyclin B