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Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites.

Abstract:

BACKGROUND: Malaria transmission may be considered to be homogenous with well-mixed parasite populations (as in the classic Ross/Macdonald models). Marked fine-scale heterogeneity of transmission has been observed in the field (i.e., over a few kilometres), but there are relatively few data on the degree of mixing. Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-popul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0021711

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
NIHR Biomedical Research Centre Oxford More from this funder
GlaxoSmithKline Biologicals More from this funder
University of Copenhagen Program of Excellence More from this funder
Foundation for the National Institutes of Health More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
6
Article number:
e21711
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
Keywords:
UUID:
uuid:361ea51f-a8bd-480e-8ce0-7012a8476ad4
Local pid:
pubs:166440
Source identifiers:
166440
Deposit date:
2012-12-19

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