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High dimensional endophenotype ranking in the search for major depression risk genes

Abstract:

Background: Despite overwhelming evidence that major depression is highly heritable, recent studies have localized only a single depression-related locus reaching genome-wide significance and have yet to identify a causal gene. Focusing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated individuals using categorical diagnoses, should improve the likelihood of identifying major depression genes. However, th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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ChemGenex Pharmaceuticals More from this funder
SBC Foundation More from this funder
Publisher:
Elsevier Inc. Publisher's website
Journal:
Biological Psychiatry Journal website
Volume:
71
Issue:
1
Pages:
6-14
Publication date:
2012-01-01
DOI:
ISSN:
0006-3223
URN:
uuid:361d8294-0973-4555-913d-ec7bafd98c71
Source identifiers:
446002
Local pid:
pubs:446002

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