- Abstract:
-
Background: Despite overwhelming evidence that major depression is highly heritable, recent studies have localized only a single depression-related locus reaching genome-wide significance and have yet to identify a causal gene. Focusing on family-based studies of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated individuals using categorical diagnoses, should improve the likelihood of identifying major depression genes. However, th...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.biopsych.2011.08.022
-
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- Publisher:
- Elsevier Inc. Publisher's website
- Journal:
- Biological Psychiatry Journal website
- Volume:
- 71
- Issue:
- 1
- Pages:
- 6-14
- Publication date:
- 2012-01-01
- DOI:
- ISSN:
-
0006-3223
- URN:
-
uuid:361d8294-0973-4555-913d-ec7bafd98c71
- Source identifiers:
-
446002
- Local pid:
- pubs:446002
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Shepperd family, Society of Biological Psychiatry, and Azar family
- Copyright date:
- 2012
- Notes:
- Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. The full text of this article is not currently available in ORA.
Journal article
High dimensional endophenotype ranking in the search for major depression risk genes
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